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It's these users that typically turn up in emergency departments and pose a challenge to medical staff, said David Caldicott, an Emergency Consultant at the Calvary Hospital in Canberra. This is caused by methamphetamine's release of another neurotransmitter (brain chemical) called noradrenaline, which induces a fight or flight response. This can escalate to feelings of intense paranoia or psychotic episodes. Once you start taking higher doses you may also start to feel jumpy or anxious, hostile and aggressive. Physically this might involve a racing heart and increased breathing rate, a rise in body temperature, a dry mouth and sometimes nausea and vomiting.Īt critical toxicity or overdose levels, people can also have stroke or heart failure, and occasionally seizures. Once users start to take ice at higher doses or to use it more frequently, the pleasurable effects tend to give way to less pleasurable ones, Dr Lee said. "The 'come down' period is like a hangover, a recovery period after which people may move into withdrawal if they are dependent," she said. Some people may also feel very irritable or have mild psychotic symptoms like paranoia and hallucinations.

You may feel exhausted and want to sleep for a day or two, although you may have difficulty sleeping, Dr Lee said. It's pretty common to feel flat, depressed, jittery and anxious.

You may also have headaches, blurred vision and start to feel hungry. So you'll have trouble making decisions, poor concentration and difficulty planning. If you're coming down from methamphetamine you're likely to feel the opposite of what you feel when you're high.

People with schizophrenia are far more likely to experience psychosis after using methamphetamine than other users.Īfter the effects of the drug wear off, you'll begin to come down, sometimes up to 24 hours after you used the drug.

These symptoms can vary in intensity and usually last up to two to three hours, but sometimes symptoms can be severe and last for days.

Methamphetamine psychosis typically involves feeling overly suspicious, having strange beliefs about things that are not plausible, or hearing and seeing things that are not there.

Almost one quarter of regular methamphetamine users will experience a symptom of psychosis in any given year.

The effects usually last for between four and 12 hours, although methamphetamine can be detected in blood and urine for up to 72 hours. Physical effects can include dilated pupils, an increased heart and breathing rate, a reduced appetite and an increased sex drive. This is because methamphetamine dramatically increases the levels of the hormone dopamine - by up to 1,000 times the normal level – much more than any other pleasure seeking activity or drug. Users say they have lots of energy and can think clearly, feel like they can make good decisions, and plan effectively. The immediate effects from ice are intense pleasure and clarity. Whereas if you ingest it through your stomach it's about 20 minutes before you start to feel the effects." "If you smoke it, it has an immediate high, just in a couple of minutes you'll get quite a big hit. Sometimes people dissolve it into alcohol or water and drink it.

"Mostly people will smoke, inject or swallow a pill," she said. How quickly you feel the effect of methamphetamine depends on the form, the route of administration and how much of it you use, Dr Lee said.